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Phentolamine injekciója a péniszbe

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    Mechanism[ edit ] Its primary action is vasodilation due to α1 blockade.

    phentolamine injekciója a péniszbe

    Like the selective α1 blockers, phentolamine causes a relaxation of systemic vasculature, leading to hypotension. This hypotension is sensed by the baroreceptor reflexwhich results in increased sympathetic nerve firing on the heart, releasing norepinephrine.

    phentolamine injekciója a péniszbe

    In response, the β1 adrenergic receptors on the heart increase their phentolamine injekciója a péniszbecontractilityand dromotropywhich help to offset the decrease in systemic blood pressure.

    Unlike the α1 selective blockers, phentolamine also inhibits the α2 receptors, which function predominantly as presynaptic negative feedback for norepinephrine release.

    phentolamine injekciója a péniszbe

    By abolishing this negative feedback phentolamine leads to even less regulated norepinephrine release, which results in a more drastic increase in heart rate. Phentolamine should only be given to patients who do not fully respond to benzodiazepinesnitroglycerinand calcium channel blockers.

    phentolamine injekciója a péniszbe

    When injected into the penis intracavernosalit increases blood flow to the penis, which results in an erection. Epinephrine infusions are less vasoconstrictive than norepinephrine as they primarily stimulate β receptor more than α receptors, but the effect remains dose-dependent.

    phentolamine injekciója a péniszbe

    Phentolamine also has merevedés 53 férfiban and therapeutic roles in complex regional pain syndrome reflex sympathetic dystrophy. Branded as OraVerse, it is a phentolamine mesylate injection designed to reverse the local vasoconstrictor properties used in many local anesthetics to prolong anesthesia.

    phentolamine injekciója a péniszbe